BUTLER DAVID,JUNG MICHAEL E.,JAYARAMAN MUTHUSAMY,MANOHARAN MUTHIAH,RAJEEV KALLANTHOTTATHIL G.
申请号：
NZ62198110
公开号：
NZ621981A
申请日:
2010.05.05
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
The disclosure relates to the 2-imidazolidinone-ethyl-piperazine derivative compounds represented by the formulae shown herein. Also described is a composition comprising: A sterol, A neutral lipid, A PEG or PEG-modified lipid, and A lipid of formula (I) which contains piperazine or amine moieties. Also disclosed are methods of making compounds such as 1-cyanomethyl-4-(2- ((cyanomethyl)amino)ethyl)piperazine. The lipid composition is useful for therapeutic agent delivery of nucleic acids as well as nucleic acid-lipid particle compositions.
