Travis Mickle,Sven Guenther,Sanjib Bera,Bindu Bera,Jaroslaw Kanski,Andrea Martin
申请号：
US15812730
公开号：
US10144740B2
申请日:
2017.11.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxycodone (4,5-α-epoxy-14-hydroxy-17-methylmorphinan-6-one) to form novel prodrugs/compositions of oxycodone, including benzoates, salicylates, propionates, fenamates, and acetates, which have a decreased potential for abuse of oxycodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
