Benzoic acid, benzoic acid derivatives and heteroarylcarboxylic acid conjugates of oxycodone

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专利权人:

ケムファーム・インコーポレーテッド

发明人:

ミクル，トラヴィス,グンサー，スヴェン,ベラ，サンジブ,ベラ，ビンドゥ,カンスキ，ヤロスロウ,マーティン，アンドレア・ケイ,ミクル,トラヴィス,グンサー,スヴェン,ベラ,サンジブ,ベラ,ビンドゥ,カンスキ,ヤロスロウ,マーティン,アンドレア・ケイ

申请号：

JP2017528967

公开号：

JP6400848B2

申请日:

2015.11.25

申请国别(地区):

JP

年份:

2018

代理人:

摘要：

The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxycodone (4,5-α-epoxy-14-hydroxy-17-methylmorphinan-6-one) to form novel prodrugs/compositions of oxycodone, including benzoates, salicylates, propionates, fenamates, and acetates, which have a decreased potential for abuse of oxycodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/