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Benzoic acid, benzoic acid derivatives and heteroarylcarboxylic acid conjugates of oxycodone
专利权人:
ケムファーム・インコーポレーテッド
发明人:
ミクル,トラヴィス,グンサー,スヴェン,ベラ,サンジブ,ベラ,ビンドゥ,カンスキ,ヤロスロウ,マーティン,アンドレア・ケイ,ミクル,トラヴィス,グンサー,スヴェン,ベラ,サンジブ,ベラ,ビンドゥ,カンスキ,ヤロスロウ,マーティン,アンドレア・ケイ
申请号:
JP2017528967
公开号:
JP6400848B2
申请日:
2015.11.25
申请国别(地区):
JP
年份:
2018
代理人:
摘要:
The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxycodone (4,5-α-epoxy-14-hydroxy-17-methylmorphinan-6-one) to form novel prodrugs/compositions of oxycodone, including benzoates, salicylates, propionates, fenamates, and acetates, which have a decreased potential for abuse of oxycodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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