JEONG, Eui Joon,정의준,MOON, Mi Jin,문미진,KIM, Jeong A,김정아,JUNG, Sung Youb,정성엽
申请号：
KRKR2017/015055
公开号：
WO2018/117613A1
申请日:
2017.12.19
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a brain targeting long-acting conjugate comprising a brain targeting peptide and a physiologically active substance, the long-acting conjugate passing through the blood-brain barrier and comprising a physiologically active substance with enhanced persistence and stability, and a method for producing the same. The brain targeting long-acting conjugate comprising a brain targeting peptide and a physiologically active substance of the present invention can pass through the blood-brain barrier to treat a disorder related to brain diseases, and provided is also a brain targeting long-acting conjugate comprising a brain targeting peptide and a physiologically active substance in which activity of the physiologically active substance is maintained in vivo and blood half-life is increased.La présente invention concerne un conjugué à action prolongée ciblant le cerveau comprenant un peptide ciblant le cerveau et une substance physiologiquement active, le conjugué à action prolongée traversant la barrière hémato-encéphalique et comprenant une substance physiologiquement active ayant une persistance et une stabilité améliorées, et un procédé de production de celui-ci. Le conjugué à action prolongée ciblant le cerveau comprenant un peptide de ciblage cérébral et une substance physiologiquement active de la présente invention peut traverser la barrière hémato-encéphalique pour traiter un trouble lié à des maladies cérébrales, et l'invention concerne en outre un conjugué à action prolongée ciblant le cerveau comprenant un peptide ciblant le cerveau et une substance physiologiquement active dans lequel l'activité de la substance physiologiquement active est maintenue in vivo et la demi-vie dans le sang est augmentée.본 발명은 뇌 표적 펩타이드 및 생리활성 물질을 포함하는 뇌 표적 지속형 결합체에 관한 것으로, 뇌혈관 장벽을 통과하고, 지속성과 안정성이 향상된 생리활성 물질을 포함하는 지속형 결합체 및 이의 제조방법에 관한 것이다. 본 발명의 뇌 표적 펩타이드 및 생리활성 물질을 포함하는 뇌 표적 지속형 결합체는 뇌혈관 장벽을 통과하여 뇌 질환에 관련된 질병의 치료가 가능하고, 또한 생리활성 물질의 활성이 생체 내에서 유지되고 혈중
