WU, YANG CHANG,吴永昌,吳永昌,CHANG, FANG RONG,张芳荣,張芳榮,LIU HUANG, ROSA,刘黄惠珠,劉黃惠珠,DU, YING CHI,杜英齐,杜英齊,TU, SHU FEN,涂淑芬,涂淑芬,YANG, JUAN CHENG,杨颛丞,楊顓丞
申请号：
TW102101197
公开号：
TWI526422B
申请日:
2013.01.11
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
This invention relates to the extract extracted from Clinacanthus nutans, entadamides, and the compounds of formula (I), as well as the preparation method thereof, wherein the R1 and R2 groups of the compounds of formula (I) are described as the specification. The aforementioned extract, entadamides or the compounds of formula (I) have the potential in antitoxicity in cancer cells, anti-inflammation and the regulations in immunity.本發明涉及從青箭(也稱優遁草和沙巴蛇草)萃取的萃取物、榼藤醯胺類化合物以及式I化合物及其製備方法,其中該式I化合物之R1及R2基團如說明書所述。前述萃取物、榼藤醯胺類化合物或式I化合物具有毒殺癌細胞、抗發炎、調節免疫力之潛力。10‧‧‧經乾燥的青箭地上部12‧‧‧乙醇萃取物14‧‧‧乙酸乙酯層16‧‧‧正己烷層18‧‧‧水摻乙醇層20‧‧‧劃分層122‧‧‧劃分層8.924‧‧‧劃分層1326‧‧‧劃分層1528‧‧‧劃分層2030‧‧‧化合物8~1632‧‧‧化合物1、2、3、634‧‧‧化合物4、5、736‧‧‧水層38‧‧‧正丁醇40‧‧‧水層S1‧‧‧95%乙醇萃取S2‧‧‧乙酸乙酯及水分配萃取S3‧‧‧水摻乙醇及正己烷分配萃取S4‧‧‧矽膠管柱層析S5‧‧‧水及正丁醇分配萃取
