PURPOSE: A composition containing eel extract for preventing and treating metabolic syndrome is provided to promote AMPK-dependent saccharide absorption.CONSTITUTION: A composition for preventing or treating metabolic syndrome contains eel extract as an active ingredient. The extract is prepared from skin, bone, intestine, or muscle of eel or whole eel using ethanol, hexane, ethyl acetate, butanol, or water. A method for preparing the extract comprises: a step of preparing eel ingredients a step of extracting the eel ingredients with ethanol a step of adding water to the ethanol fraction and a step of adding hexane and extracting.COPYRIGHT KIPO 2013[Reference numerals] (AA) Eel skin (BB) Eel bone & intestine (CC) Eel muscle (DD,EE) 2DG Uptake(pmole2DG/min/mg)본 발명은 장어 추출물을 유효성분으로 함유하는 대사증후군 예방 및 치료용 조성물에 관한 것으로, 상기 장어 추출물은 AMPK(AMP-Activated Protein Kinase)를 활성화시키고, 포도당의 흡수를 촉진시키며, ACC(acetyl-CoA carboxylase) 단백질들을 직접 인산화시키며, AMPK 활성화를 통해 AMPK 의존적 당 흡수를 촉진시키는 효능이 있기 때문에, 비만, 당뇨병 등을 포함한 대사증후군의 예방 및 치료를 위한 조성물 및 기능성 식품으로서 유용하게 이용될 수 있다.
