SPIROCYCLIC MOLECULES AS PROTEIN KINASE INHIBITORS

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专利权人:

Zhaoyin Wang

发明人:

Zhaoyin Wang,Lianhai Li,Zhigang Wang

申请号：

US14234586

公开号：

US20140243303A1

申请日:

2012.07.26

申请国别(地区):

US

年份:

2014

代理人:

摘要：

The present invention relates to spirocyclic compounds of formula I, namely spirocyclic (1H-pyrazol-4-yl)-3-(1-(2,6-dichloro-3-fiuorophenyl)ethoxy)pyridin-2-amines having protein kinase inhibitory activity, and methods of synthesizing and using such compounds. Preferred compounds are c-Met and/or ALK inhibitors useful for the treatment of abnormal cell growth, such as cancers.R2 is selected from

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