Buettelmann, Bernd,Knust, Henner,Thomas, Andrew,Jakob-Roetne, Roland
申请号：
AU2008333327
公开号：
AU2008333327B2
申请日:
2008.11.26
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention relates to compounds of formula (I) wherein X is O or NH； Ris phenyl, pyridinyl, or pyrimidinyl each optionally substituted with one,two or three halo, R is Calkyl, H or Chaloalkyl；R, R, and R each are independently H, optionallysubstituted Ci-7alkyl, optionally substituted Cι.7alkoxy, CN, halo,NO2, -C(O)-R -NRR, optionally substituted3- to 7-membered heterocyclyl, optionally substituted 5- or 6-membered heteroaryl,-C(0)-NRR, or R together with the neighboringpyridazine-nitrogen form a 5-membered optionally substituted annelated aromaticring with two additional ring nitrogen atoms, or to a pharmaceutically acceptablesalt thereof, having affinity and selectivity for the GABA A α5 receptorbinding site, their manufacture, pharmaceutical compositions containingthem and their use as medicaments. The active compounds of the present inventionare useful as cognitive enhancers or for the treatment of cognitive disorderslike Alzheimer's disease.
