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SUBSTITUTED 3-HETEROAROYLAMINOPROPHIC ACID DERIVATIVES AND THEIR APPLICATION AS MEDICINES
专利权人:
САНОФИ (DE)
发明人:
РУФ Свен (DE),САДОВСКИ Торстен (DE),ВИРТ Клаус (DE),ШРОЙДЕР Херман (DE),БУНИНГ Кристиан (DE)
申请号:
RU2013139349/04
公开号:
RU2013139349A
申请日:
2012.01.26
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. The compound of formula I, in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, or its physiologically acceptable salt, or physiologically acceptable solvate of any of them, where A is selected from the group consisting of C (R) and N; D is selected from the group consisting of C (R) and N; E is selected from the group consisting of C (R) and N; L is selected from the group consisting of C (R) and N; where at least one and not more than two of A, D E or L is N; G is selected from the group consisting of ROC (O) -, RN (R) -C (O) - and tetrazol-5-yl; R is selected from the group consisting of hydrogen, halogen, (CC) -alkyl , HO-, (CC) -alkyl-O-, (CC) -alkyl-S (O) - and NC-; R are selected from the group consisting of hydrogen, halogen, (CC) -alkyl, (CC) -alkyl-O-, (CC) -alkyl -CO-, (CC) -alkyl-CO-HN-, -NRR, Het, (CC) -cycloalkyl-CH- and Ar-CH-, where s is an integer from the series consisting of 0, 1, 2 and 3 ; R is selected from the group consisting of hydrogen, halogen, (CC) -alkyl, (CC) -alkyl-S (O) -, Het- (O), -NRR, Het, RO-, RN (R) -C (O ) -O- and Het-C (O) -O- and NC-, where s is an integer from a series of 0, 1, 2 and 3, and where t is an integer from a series of 0 and 1; R is selected from the group consisting of hydrogen, halogen, (CC) -alkyl, (CC) -alkyl-O-, HO-, NRR, Het; R is selected from the group comprising hydrogen, halogen, (CC) -alk l, (CC) -alkyl-O-, (CC) -alkyl-S (O) -, HO-, -NRR, Het, phenyl-CH- (O) -, where s is an integer from the series including 0 , 1, 2, and 3, and where t is an integer from a series including 0 and 1; or R and R or R and R form pyridyl; or R and R are —C ((CC) -alkyl) = NN ((CC) -alkyl) - ; or R and R are —NH — CH = N—; provided that one of R, R, R, R or R is a cyclic substituent; R is selected from the group consisting of hydrogen, R, (CC) cycloalkyl, Ar and Het; R and R are independent each other is selected from the group consisting of hydrogen and R; R is (C-C) -alkyl, which is option
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