ВЕРДИН Грегори Л. (US),МИНА Мина (US),ИВАМОТО Наоки (US)
申请号：
RU2012102480/04
公开号：
RU2012102480A
申请日:
2010.07.06
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. An oligonucleotide composition containing a plurality of oligonucleotides of the following structure: where R is —OH, —SH, —NRR, —N, halogen, hydrogen, alkyl, alkenyl, alkynyl, alkyl-Y-, alkenyl-Y-, alkynyl-Y- , aryl-Y-, heteroaryl-Y-, -P (O) (R), -HP (O) (R), -OR or -SR； Y is O, NR, S or Se； R is a blocking group； R is a blocking group； R is is a blocking group； R, in each case independently, is hydrogen, alkyl, alkenyl, alkynyl, aryl, acyl, substituted silyl, carbamate, -P (O) (R) or -HP (O) (R)； R, in each case independently, represents hydrogen, al keel, aryl, alkenyl, alkynyl, alkyl-Y-, alkenyl-Y-, alkynyl-Y-, aryl-Y- or heteroaryl-Y- or a cation which is Na, Li or K； Y is O, NR or S； R, in each case independently, is hydrogen, —OH, —SH, —NRR, —N, halogen, alkyl, alkenyl, alkynyl, alkyl-Y-, alkenyl-Y-, alkynyl-Y-, aryl-Y- , heteroaryl-Y-, -OR, or -SR, where R is a blocking group； Ba, in each case independently, is a blocked or non-blocked adenine, cytosine, guanine, thymine, uracil or a modified nucleic base； where in each case e fragment X is H or -OCHCHS-S (O) R, -OCHCHS-SCHCHOH, -OCHCHCOH ,,,,,,,,,,,,,,,,, and at least 25% of X present in the oligonucleotide are other than H； where R is an alkyl group which contains from 1 to 4 carbon atoms； R 1 is alkyl, aryl, heteroaryl, heterocyclyl or cycloalkyl； and R 1 is hydrogen or alkyl； R 1 is hydrogen blocking a group linking a moiety connected to a solid support or connected to a nucleic acid； and n is an integer from 1 to about 2001. Олигонуклеотидная композиция, содержащая множество олигонуклеотидов следующей структуры:где Rпредставляет собой -ОН, -SH, -NRR, -N, галоген, водород, алкил, алкенил, алкинил, алкил-Y-, алкенил-Y-, алкинил-Y-, арил-Y-, гетероарил-Y-, -Р(O)(R), -HP(O)(R), -ORили -SR；Yпредставляет собой О, NR, S или Se；Rпредставляет собой блокирующую группу；Rпредставляет собой блокирующую группу；R, в каждом случае независимо, представляет собой водород, алкил, алкенил, алкинил, арил, ацил, замещенны
