The present invention relates to C ompounds having the structure of Formula I: whereinn is an integer from 1 to 5； R is optionally substituted alkyl, alkenyl,alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy,alkenyloxy or alkynyloxy； R is alkenyl, allcynyl, aryl, heterocyclyl,heteroaryl, cycloalkyl, NRR, -NHC(=Y)R, -NHC(=Y)NRR, -NHC(=O)OR, -NHSOR, C(=Y)NRR,C(=O)OR [wherein Y is oxygen or sulphur], OR, -O(C=O)NRR,O-acyl, S(O)R, -SON(R),cyano, amidino or guanidino [wherein R is alkyl, alkenyl, alkynyl,cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, heterocyclylalkylor cycloalkylalkyl and m is an integer 0-2； R is hydrogen or R；R is R or -SON(R) andR is hydrogen, alkyl, cycloalkyl, aralkyl, heteroarylalkyl, heterocyclylalkylor cycloalkylalkyl]； R is hydrogen, fluorine, alkyl, cycloalkylalkylor aralkyl； A is OH, OR, -OC(=O)NRR, O-acyl,NH, NRR, -NHC(=Y)R, -NHC(=Y)NRR, -NHC(=O)OR, -NHSOR, and to processes for thesynthesis of the same. This invention also relates to pharmacological compositions containingthe compounds of the present invention, and methods of treating asthma, rheumatoidarthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis,pulmonary fibrosis pulmonary inflammation, acute respiratory distress syndrome,perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimalproliferation, which leads to restenosis and ischemic heart failure, stroke,renal diseases, tumor metastasis, and other inflammatory disorders characterizedby over-expression and over-activation of an matrix metalloproteinase, usingthe compounds.
