FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry, and specifically to novel spiroindolinone pyrrolidine derivatives of general formulaor pharmaceutically acceptable salts and enantiomers thereof, where X is selected from a group which includes Cl and Br, Y is selected from a group which includes F, Cl and Br, Ris a substituted lower alkyl selected from:where R, Rare both a methyl； Ris (CH)-R； Ris selected from hydrogen, hydroxyl； q = 1 or 2； Ris selected from a group which includes phenyl, phenyl substituted with 1-3 substitutes, heteroaryl and heteroaryl substituted with 1-2 substitutes, where the heteroaryl is selected from pyrrolyl, pyrazolyl, furanyl, thiophenyl, thiazolyl, pyridinyl, pyrimidinyl, benzothiophenyl； where the substitutes for the substituted phenyl and the substituted heteroaryl are selected from a group which includes hydrogen, lower alkyl, halogen, CN, NH, N(H, lower alkyl), N(lower alkyl), aminocarbonyl, lower dialkylaminocarbonyl, carboxy, NO, lower alkoxy, lower alkylsulphonyl, lower alkylcarbonyl, lower alkoxycarbonyl, lower alkylcarbonyl-NH, lower alkoxycarbonyl-lower alkoxy, lower alkylcarbonyl-oxy-lower alkoxy, carboxy-lower alkoxy, hydroxy-lower alkoxy, lower alkyl-thio-lower alkoxy, lower alkylsulphonyl-lower alkoxy, aminocarbonyl-lower alkoxy, lower alkylthionyl-lower alkoxy, halogen-lower alkoxy, dimethylmorpholine, morpholine, tetrazole, lower alkylsulphonylamino, hydroxy-lower alkylcarbonyl, morpholine-4-sulphonyl, tetrahydropyranoxy, -NH-CH-COOH, -NH-CH-COOEt, -CONH-CN, oxo-group and lower alkyl, which is substituted with one substitute selected from hydroxy, lower alkoxycarbonyl, lower alkylcarbonyl, carboxy, aminocarbonyl； R, R, Rare selected from H or F under the condition that at least two of R, R, Rare hydrogen； R, R, Rare selected from H or F under the condition that at least two of R, R, Rare hydrogen. The invention also relates to a compound of formulawhere the values of radicals are given in the claim, spe
