A compound having the formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate or a pharmaceutically acceptable salt thereof, ** (See formula) ** where, each of Q1 and Q2 is independently N or CH； X is N or CH； J is -O-, -C (>； = S) -, - (CH2) mO-, -C (>； = O) -, -C (>； = O) O-, -S (>； = O) 1- , - (CH2) mN (R6) -, -N (R6) -, -S (>； = O) 1N (R6) -, -CH>； = CH-, - N (R6) C (>； = O) - or - (CH2) m-； each R1 is independently -Y-R5, where each Y is independently -O-, -C (>； = S) -, - (CH2) mO-, - C (>； = O) -, -C (>； = O ) O-, -S (>； = O) 1-, - (CH2) mN (R6) -, -N (R6) -, -S (>； = O) tN (R6) -, -CH>； = CH- , -N (R6) C (>； = O) - or - (CH2) m-； each R1a is independently H, F, Cl, Br, I, cyano, hydroxy, amino, carboxy, alkyl, haloalkyl, alkoxy, alkylamino, alkylthio, alkenyl, alkynyl, nitro, mercapto, hydroxyalkoxy, hydroxyalkyl, aminoalkoxy, alkyl (-OC (>； = O) -, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl, aryloxy, heteroaryloxy, haloalkoxy or cycloalkylalkyl； each of R2 and R3 is independently H, F, Cl, Br, I, cyano, hydroxy , carboxy, alkyl, haloalkyl, alkoxy, hydroxyalkoxy, hydroxyalkyl, aminoalkoxy, haloalkoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl or cycloalkylalkyl； each R4 is independently H, hydroxy, carboxy Cl, F , I, cyano, nitro, mercapto, alkyl, haloalkyl, alkoxy, alkylamino, alkylthio, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl or cycloalkylalkyl； each R5 is independently heterobic bridged icyl, bridged bicyclyl, condensed bicyclyl, condensed heterobicyclyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl or cycloalkylalkyl； each R6 is H； each t is independently 0, 1 or 2； each m is independently 1, 2, 3 or 4； each of n and p is independently 0, 1, 2, 3 or 4； and k is 1, 2, 3 or 4； where each of - (CH2) m
