The present invention provides deuterium-enriched heteroaryl-containing urea compounds (I) and use of the same of treating conditions mediated by protein kinase such as VEGFR2, PDGFRβ, EphB4 or c-Met.本發明提供了一類如分子式(I)所示的氘富集化的含有雜芳基的脲以及其在治療蛋白激酶(例如VEGFR2,PDGFRβ,EphB4或c-Met)中介的病症中的應用。