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DERIVADOS DE ANILLOS FUSIONADOS DE 9 MIEMBROS CON ACCIÓN SOBRE ACETIL CoA CARBOXILASA
专利权人:
SHIONOGI & CO.; LTD.
发明人:
申请号:
ARP160100831
公开号:
AR104121A1
申请日:
2016.03.29
申请国别(地区):
AR
年份:
2017
代理人:
摘要:
Compounds with Selective Inhibitory activity of ACC2. In addition, a Pharmaceutical composition comprising the compound.Claim 1: a compound characterized by the formula (1) or its pharmaceutically acceptable Salt, where r\u00b9 heterociclilo FUSED Aromatic substituted or unsubstituted represented by the formula (2) where B ring is a Ring of five members c ring ring ring 6 is a member It is not carbociclo Aromatic substituted or non substituted,Non Aromatic heterocycle substituted or unsubstituted Aromatic, carbociclo replaced or not replaced or substituted or unsubstituted Aromatic heterocycle substituted l\u00b9 - - - O - (cr\u2076r\u2077) \u2098 -, - N (r\u2078) - (\u2098 cr\u2076r\u2077) - or - (cr\u2076r\u2077) \u2098 - Where the link on the left side joins r\u00b9, Link L Ado right joins the Ring L\u00b2 - - - O - (cr\u2076r\u2077) \u2099 -, - or - cr\u2076 cr\u2077 = - - = cr\u2076 cr\u2077 - or - (cr\u2076r\u2077) \u2099 -The link on the left side where it joins with the ring, the link on the right side joins the Group represented by the formula (3) each r\u2076 is independently Hydrogen, halogen, alkyl, cyano, substituted or unsubstituted or substituted or unsubstituted, alquenilo alquinilo sust Ituido or not replaced each r\u2077 is independently Hydrogen, halogen, a cyano,Alkyl substituted or non substituted or unsubstituted or substituted, alquenilo alquinilo replaced or not replaced r\u2076 and r\u2077 at the same carbon Atom can be taken along with the carbon Atom to form the Ring r\u2078 is Hydrogen or alkyl substituted or non substituted each M is, mod Or independent, an integer of 0, 1, 2 or 3 each independently, N is an integer of 12 or 3 alkyl R\u00b2 is replaced or not replaced r\u00b3 is Hydrogen or alkyl substituted or non substituted r\u2074 alquilcarbonilo is replaced or not replaced, alquenilcarbonilo replaced or not replaced, alquinilcarbonilo replaced or not replaced or not replaced, carbociclilcarbonilo Aromatic Carbociclilcarbonilo unsubs
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