Compounds with therapeutic flammability and autoimmunity. Claim 1: a compound characterized by formula (1) or a salt acceptable for the same agent, wherein X can be o, s (o) 691,Nr,C (o) or ch832222；A1 and A2 can be CRU or n respectively； A3,A83088 and a83099 can be carried out independently,C (R)N o NRAs long as there are at least three A1's,...A3,A8308；A83099,a. A8310c is an independent CRU or C (R2) 8322；- - - - - indicates a single or double link； R¹ can be an alkyl C₆₋₂₀,a Cc carbocyclyl,a 3- to 15-membered heterocyclyl, a C₆₋₁₀ aryl,O 5 to 14 element heteromorphisms, wherein the isomer and the isomer are composed of 1 to 10 selected heteroatoms independent of N, s, u or O, wherein R1 can be substituted from the independently selected 1 to 6 r8310；a. For each substance, it can be selected independently from hydrogen, halogen, hydroxyl, nitro, cyanogen, carboxi and hydrocarbyl c83321316c；haloalkyl C₁₋₆,cycloalkyl C₃₋₈,Halogenated ring 12C₁₋₆ alkoxy,haloalkoxy C₁₋₆,cycloalkoxy C₃₋₈,Cc halocycloalkoxy,2. Scope: c83218c83316262；amino N- (alquilo C) amino N N-di- (alquilo C) amino alcoxicarbonilo CC₁₋₆ alkanoyloxy,carbamoyl, N- (C₁₋₆-alkyl) carbamoyl, N, N-di- (C₁₋₆-alkyl) carbamoyl, C₁₋₆-alkylamido,mercapto, alkylthio C₁₋₆,C₁₋₆ alkylsulfonyl,1. Sulfuric acid, N - (c832131 tar)；R³ can be hydrogen, a halo, C₁₋₆ haloalkyl or cyano, provided that when R³ is hydrogen, R¹ is a C₃₋₈ cycloalkyl which is optionally substituted from 1 to 6； R⁴ is a carboxylic acid or a group represented by formula (2) where the wavy line represents the point of attachment； provided that when R⁴ is a carboxylic acid, A¹ is N and R¹ is a C₃₋₈ cycloalkyl which is optionally substituted from 1 to 6； R⁵ can be an alkylene C₁₋₆,carbocyclyl C₃₋₈,a. 3-A 8-element isopropene, arilo c8332626 and 83318321； 8320；a 5- to 10-element heteroaryl, a bridged ring system comprising 6 to 12 ring elements, a spiro ring system comprising 5-14 ring elements, or a bicyclic ring system represented by formula (3) whe
