This invention discharge of the medicine regards the production manner of the sustained-release microsphere which the long period of time it can adjust. Furthermore as for details, as for this invention, early overage discharge of the bioactive substance is suppressed at the time of producing the microsphere where the medicine is enclosed in the substrate which includes the biodegradation Characteristic macromolecule, the bioactive substance with internal to discharge in order, also the solvent alternating current evaporation modulo due to the means of the solvent is used continuance and uniformly, it regards the production manner of the sustained-release microsphere.< Choice figure > Drawing 1本発明は、薬物の放出を長期間調節し得る徐放性マイクロスフェアの製造方法に関する。さらに詳しくは、本発明は、生分解性高分子を含む担体中に薬物が封入されたマイクロスフェアの製造において、生理活性物質の初期過多放出を抑制し、生理活性物質を体内で持続的かつ均一に放出するために、共溶媒の手段による溶媒交流蒸発法を用いる、徐放性マイクロスフェアの製造方法に関する。【選択図】 図1
