YAMAMOTO, KEIICHIROU,OKAZAKI, MANAMI,KAWAMURA, DAI
申请号：
CA2816997
公开号：
CA2816997A1
申请日:
2011.11.16
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
[Problem] To provide a novel polymer derivative of a cytidine metabolism antagonist with which drug release is possible independent of a biological enzyme and with which a highly therapeutic effect is expected. [Solution] A polymer derivative of a cytidine metabolism antagonist in which substituent groups represented by general formula (I) or general formula (II) [where R7 and R8 are each independently a hydrogen atom or C1-6 alkyl group optionally having substituent groups； R6 is a hydrogen atom, C1-40 alkyl group optionally having substituent groups, C1-40 aralkyl group optionally having substituent groups, aromatic group optionally having substituent groups, amino acid residue protected by carboxy groups, or sugar residue optionally having substituent groups； CX-CY is CH-CH or C=C (double bond)； and A is a residue in which the amino group at position 4 has been removed from the cytidine metabolism antagonist] are bonded to the side chain carboxy groups of a block copolymer formed by a polyethylene glycol structural segment and a polymer having ten or more carboxy groups.
