胞嘧啶核苷系代謝拮抗劑之高分子衍生物农业专利-农业学术服务平台

发明人:: MASUDA, AKIRA,增田亮,增田亮,ONDA, TAKESHI,恩田健,恩田健,MASHIBA, HIROKO,真柴洋子,真柴洋子,YAMAMOTO, KEIICHIROU,山本启一朗,山本啟一朗,TAKASHIO, KAZUTOSHI,高盐一俊,高鹽一俊

摘要：: [PROBLEMS] To provide a derivative of a cytidine metabolic antagonist which can exert a high therapeutic effect at a low dose. [MEANS FOR SOLVING PROBLEMS] A polymeric derivative of a cytidine metabolic antagonist which comprises a polymeric compound having a polyethylene glycol moiety and a polymer moiety having a carboxyl group in a side chain and a cytidine metabolic antagonist, which has such a structure that the carboxyl group in the side chain of the polymeric compound and an amino group in the cytidine metabolic antagonist are bound together to form an amide bond.本發明提供一種胞嘧啶核苷系代謝拮抗劑之衍生物,業者期望以低投與量而獲得較高之治療效果。本發明提供一種胞嘧啶核苷系代謝拮抗劑之高分子衍生物,其特徵在於:其具有由聚乙二醇類部分及於側鏈具有羧基之聚合物之部分所構成之高分子化合物之側鏈羧基、與胞嘧啶核苷系代謝拮抗劑之胺基進行醯胺鍵結之結構。