THE UNITED STATES OF AMERICA; as represented by the SecretaryDepartment of Health and Human Servic
发明人:
Kapil Bharti,Min Jae Song,Russell Louis Quinn
申请号：
US16347939
公开号：
US20190290803A1
申请日:
2017.11.08
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Methods are disclosed for fabricating a three-dimensional engineered blood retinal barrier (BRB) comprising a choroid and retinal pigment epithelial cells. The methods include the use of bioprinting. Also disclosed is a three-dimensional engineered BRB, and its use. Methods are also disclosed for using the three-dimensional engineered BRB, such as for the treatment of retinal degeneration in a subject or screening. A three-dimensional printing insert that is adapted for bioprinting on a culture substrate sheet that is securely retained within and exposed through a printing frame is also disclosed.
