THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH & HUMAN SERVICES
发明人:
BHARTI, KAPIL,SONG, MIN JAE,QUINN, RUSSELL LOUIS
申请号：
CA3043194
公开号：
CA3043194A1
申请日:
2017.11.08
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Methods are disclosed for fabricating a three-dimensional engineered blood retinal barrier (BRB) comprising a choroid and retinal pigment epithelial cells. The methods include the use of bioprinting. Also disclosed is a three-dimensional engineered BRB, and its use. Methods are also disclosed for using the three-dimensional engineered BRB, such as for the treatment of retinal degeneration in a subject or screening. A three-dimensional printing insert that is adapted for bioprinting on a culture substrate sheet that is securely retained within and exposed through a printing frame is also disclosed.
