Pharmaceutical composition containing keratin 8 phosphorylation inhibitor for preventing or treating macular degeneration, and method for screening macular degeneration medicine

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专利权人:

Konkuk University Industrial Cooperation Corp

发明人:

Kim, Dong Eun,Baek, Ah Ruem

申请号：

AU2017267166

公开号：

AU2017267166B2

申请日:

2017.05.18

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

The present invention provides a pharmaceutical composition containing trametinib or gefitinib for preventing or treating macular degeneration, and a method for screening a macular degeneration medicine. The pharmaceutical composition of the present invention inhibits the phosphorylation of keratin 8 and the reorganization thereof around the nucleus in retinal pigment epithelial cells under oxidative stress conditions, increases the expression of E-cadherin, and reduces the expression of vimentin, and thus the pharmaceutical composition can be useful for the prevention or treatment of macular degeneration.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/