PHARMACEUTICAL COMPOSITION CONTAINING KERATIN 8 PHOSPHORYLATION INHIBITOR FOR PREVENTING OR TREATING MACULAR DEGENERATION, AND METHOD FOR SCREENING MACULAR DEGENERATION MEDICINE
The present invention relates to a pharmaceutical composition for preventing or treating macular degeneration containing trametinib or gefitinib, and to a method of screening a therapeutic agent for macular degeneration. The pharmaceutical composition of the present invention is capable of inhibiting the phosphorylation of keratin 8 and the reorganization thereof around nuclei in retinal pigment epithelial cells under oxidative stress conditions, increasing the expression of E-cadherin, and reducing the expression of vimentin, and can thus be efficiently useful for the prevention or treatment of macular degeneration.
