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ASSAY-READY RECOMBINANT CELLS TRANSIENTLY OVEREXPRESSING GENES ENCODING DRUG TRANSPORTER PROTEINS AND/OR DRUG METABOLIZING ENZYMES
专利权人:
发明人:
Na Li,Jie Wang,Christopher J. Patten
申请号:
US15269045
公开号:
US20170067909A1
申请日:
2016.09.19
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Recombinant cells including one or more transiently overexpressed genes encoding a drug transporter protein, wherein the recombinant cell is cryopreserved and activity of the drug transporter protein is detectable in a population of the recombinant cells prior to cryopreservation at an uptake ratio of at least 5. Processes of preparing cryopreserved transiently transfected recombinant cells, including transiently transfecting cells with one or more genes encoding a drug transporter protein and cryopreserving the transiently transfected recombinant cells within 48 hours of transfection. A population of the transiently transfected recombinant cells transiently overexpress the one or more genes encoding the drug transporter protein at a detectable level prior to cryopreserving and the detectable level is an uptake ratio of at least 5.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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