The present invention relates to an unmodified graft a modified graft and/or a CD4 antagonist (preferably a CD4 antibody) for use in a method of treating one or more disease(s) treatable by transplantation in a subject wherein said method comprises a first step of introducing into said subject a modified graft and a second step of introducing into said subject said unmodified graft wherein said modified graft is a cell graft containing immune cells wherein said modification impairs CD4. The present invention also relates to various further uses of an unmodified graft a modified graft and/or a CD4 antagonist.
