Compounds of formula I in which R1 is methoxy, R2 is methoxy, ethoxy, difluoromethoxy or 2,2-difluoroethoxy, R3 is hydrogen, R31 is hydrogen, R4 is -O-R41, in which R41 is hydrogen, R5 is hydrogen, Har is substituted by R6 and R7, and is pyridinyl, in which R6 is oxo, and R7 is methyl, or an enantiomer, a salt, a N-oxide or a salt of an enantiomer or N-oxide thereof are novel effective PDE4 inhibitors.Jedinjenje formule Iu kojojR1 je metoksi,R2 je metoksi, etoksi, difluorometoksi ili 2,2-difluoroetoksi, R3 je vodonik,R31 je vodonik,R4 je -O-R41, gdeR41 je vodonik,R5 je vodonik,Har je supstituisan sa R6 i R7, i je piridinil, gde R6 je okso, iR7 je metil,ili enantiomer, so, N-oksid ili so enantiomera ili N-oksida ovog jedinjenja.Prijava sadrži još 24 patentna zahteva.
