Lai, Katharine C.,Herbst, Robert W.,Hilderbrand, Scott Alan
申请号：
AU2017213858
公开号：
AU2017213858A1
申请日:
2017.02.03
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present invention provides a novel method for preparing a cell-binding agent cytotoxic agent conjugate. The method comprises the step of reacting a cell-binding agent with a cytotoxic agent or a cytotoxic agent-linker compound having a reactive group capable of forming a covalent bond with the cell-binding agent at a pH between 4 to 9 in the presence of a buffer solution with high ionic strength, wherein the cell-binding agent comprises a lysine ε-ΝH
