KIM, WON JONG,김원종,HWANG, DO WON,황도원,LEE, DONG SOO,이동수,SON, SE JIN,손세진
申请号：
KR1020100128622
公开号：
KR1020120067168A
申请日:
2010.12.15
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A polynucleotide delivering complex containing RVG peptide-conjugated cationic polymers is provided to effectively and safely deliver polynucleotides to target cells.CONSTITUTION: A polynucleotide delivering complex contains RVG(rabies virus glycoprotein) peptide-conjugated cationic polymers. The polymers have ester bond, amide bond, disulfice bond, phosphate bond, or combination thereof. The cationic polymers are polyethylene imine(PEI), poly-L-lysine(PLL), chitosan, or dendrimer. The polynucleotide delivering complex has non-peptidyl polymers between the RVG peptide and cationic polymers. The non-peptidyl polymers are polyethylene glycol.COPYRIGHT KIPO 2012본 발명은 RVG 펩티드가 결합된 양이온성 고분자를 포함하고, 상기 양이온성 고분자는 생분해성 결합을 포함하는 것인 폴리뉴클레오티드 전달체 및 상기 전달체를 이용하여 표적 세포에 폴리뉴클레오티드를 전달하는 방법을 제공한다.
