KIM, Seon-Mi,KIM, Jae-Sun,LEE, Minhee,LEE, So-Young,LEE, Bong-Yong,SHIN, Young Ah,PARK, Euisun,LEE, Jung A,HAN, Min-Young,AHN, Jaeseung,YOO, Taekyung,KIM, Hun-Taek
申请号：
ES13754960
公开号：
ES2613856T3
申请日:
2013.02.28
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula (I), or a stereoisomer or a pharmaceutically salt thereof: ** Formula ** wherein, A is CR8aR8b, O, S or NR9； R1 and R2, which may be the same or different, are each independently hydrogen, (C1-C10) alkyl, substituted (C1-C10) alkyl, cycloalkyl (C3-C10), substituted cycloalkyl (C3-C10), aryl (C6) -C12), substituted aryl (C6-C10), aryl (C6-C12) -alkyl (C1-C10), aryl (C6-C12) -alkyl (C1-C10) substituted, heteroaryl (C1-C20), heteroaryl ( C1-C20) substituted, heteroaryl (C1-C20) -alkyl (C1-C10), heteroaryl (C1-C20) -alkyl (C1-C10) substituted, heterocycle (C1-C20), heterocycle (C1-C20) substituted, heterocyclyl (C1-C20) -alkyl (C1-C10), heterocyclyl (C1-C20) -alkyl (C1-C10), or - (CR1aR1b) s-R12； R3a and R3b, which may be the same or different, are each independently hydrogen, (C1-C10) alkyl, substituted (C1-C10) alkyl, cycloalkyl (C3-C10), substituted cycloalkyl (C3-C10), alkoxy (C1 -C10), alkylthio (C1-C10), alkylamino (C1-C10), aryl (C6-C12), substituted aryl (C6-C12), aryl (C6-C12) -alkyl (C1-C10), aryl (C6 -C12) -substituted (C1-C10) alkyl, heteroaryl (C1-C20), substituted heteroaryl (C1-C20), heteroaryl (C1-C20) -alkyl (C1-C10), heteroaryl (C1-C20) -alkyl ( C1-C10) substituted, heterocycle (C1-C20), heterocycle (C1-C20) substituted, heterocyclyl (C1-C20) -alkyl (C1-C10), heterocyclyl (C1-C20) -alkyl (C1-C10) substituted, -COOR13 or -CONR13R14； R3a and R3b, together with the carbon atom attached thereto, form a homocyclic ring, a substituted homocyclic ring, a heterocyclic ring or a substituted heterocyclic ring； or R3a and a carbon bonded thereto, together with R1 and a nitrogen atom bonded thereto, form a heterocyclic ring or a substituted heterocyclic ring； R4 is - (CR9aR9b) r-Z-Y； ç n is an integer of 2, 3 or 4； s is an integer of 1,2, 3 or 4； r is an integer of 0, 1 or 2； Z represents a direct link, or -O-, -S-, -NR11-, -SO-, -SO2-, -OSO2-, -SO2O-, -SO2NR11-, -NR11SO2-, -CO-, -COO- , -OCO-, -CONR11-, -NR11CO-, -NR11CONR11a-, -OCONR11- or
