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Process for the preparation of SGLT2 inhibitors
专利权人:
LLC;Theracos Sub
发明人:
LIOU, Jason,WU, Yuelin,LI, Shengbin,XU, Ge
申请号:
ES09808859
公开号:
ES2599330T3
申请日:
2009.08.21
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A method for the preparation of a complex of Formula IA: ** Formula ** in which the subscript n is 1 or 2 R1 is a member selected from the group consisting of hydrogen, halo and C1-C6 alkyl; V is a member selected from the group consisting of oxygen and a single bond; W is a member selected from the group consisting of C1-C6 alkylene, C2-C6 alkenylene, C2-6 alkynylene, C3-C10 cycloalkylene, and (C3-C10 cycloalkylene) (C1-C6 alkylene); X is a member selected from the group consisting of oxygen, a single bond, and NRa; and Y is a member selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 cycloalkyl, (C3-C10 cycloalkyl) C1-C4 alkyl, (C1-C4 alkyloxy) C1-C3 alkyl, (C3-C10 cycloalkyloxy) C1-C3 alkyl, (amino) C1-C3 alkyl, (C1-C4 alkylamino) C1-C3 alkyl, (C1- alkyl C6) carbonyl, (C2-C6 alkenyl) carbonyl, (C2-C6 alkynyl) carbonyl, (C1-C6 alkyl) sulfonyl, (C2-C6 alkenyl) sulfonyl, and (C2-C6 alkynyl) sulfonyl, in which the groups alkyl, alkenyl, alkynyl and cycloalkyl or the portions of W, X and Y are optionally partially or completely fluorinated and optionally mono or disubstituted by identical or different substituents selected from chloro, hydroxy, C1-C3 alkyl, C1-C3 alkoxy, and cycloalkyl C3-C6, and in the cycloalkyl groups or portions one or two methylene groups are optionally independently replaced by O, S, CO, SO, SO2 or NRb, and one or two methine groups they are optionally replaced by N; Ra is a member independently selected from the group consisting of H, C1-C6 alkyl, C3-C6 cycloalkyl and (C1-C4 alkyl) carbonyl, wherein the alkyl and cycloalkyl groups or portions are optionally partially or completely fluorinated; each Rb is a member independently selected from the group consisting of H, C1-C4 alkyl and (C1-C4 alkyl) carbonyl, wherein the alkyl groups or portions are optionally partially or completely fluorinated; or a pharmaceutically acceptable salt thereof; comprising: (a) reactin
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