KARLA DRESCHER,JÜRGEN DINGES,ANDREAS HAUPT,ANA LUCIA RELO,LILIANE UNGER,KARSTEN WICKE,ROBERT VAN WATERSCHOOT
申请号：
MX2015012184
公开号：
MX2015012184A
申请日:
2014.03.14
申请国别(地区):
MX
年份:
2016
代理人:
摘要：
The present invention relates to novel acylaminocycloalkyl compounds, in particular to the compounds of the formula I as described herein and to their salts and N-oxides. The compounds possess valuable therapeutic properties and are suitable, in particular, for treating diseases that respond to modulation of the dopamine D3 receptor. In formula I, the variables have the following meanings: m is 1 or 2, n is 1 or 2, A is selected from the group consisting of CH2, CH2CH2, CHFCH2 and CF2CH2, R1 is an oxygen containing cyclic radical selected such as C3-C6 cycloalkyl, which carries one or two oxygen containing radicals selected from the group consisting of OH, C1-C2-alkoxy, fluorinated C1-C2-alkoxy, and a carbonyl oxygen,, R2 is selected from the group consisting of hydrogen, OH and fluorine, R3a is selected from the group consisting of hydrogen and methyl, R3b is selected from the group consisting of hydrogen and methyl, R4 is branched C4-C6 alkyl or branched fluorinated C4-C6 alkyl, and R5 is inter alia C1-C6 alkyl, fluorinated C1-C3 alkyl, C1-C2-alkoxy-C1-C4- alkyl, fluorinated C1-C2-alkoxy-C1-C4- alkyl, hydroxy-C1-C4-alkyl, fluorinated hydroxy-C1-C4-alkyl, oxetanyl, fluorinated oxetanyl, oxolanyl, fluorinated oxolanyl, C3-C5 cycloalkyl, fluorinated C3-C5 cycloalkyl, etc.La presente invención relata nuevos compuestos acilaminocicloalquil en particular a los compuestos de la fórmula I como se describe aquí y sus sales y N-óxidos. Los compuestos poseen importantes propiedades terapéuticas y son adecuadas en paricular para tratar enfermedades que corresponden a la modulación del receptor D3 de la dopamina. En la fórmula I las variables significan lo siguiente: m es 1 o 2, n es 1 o 2, A es seleccionada del grupo que consiste en CH2, CH2CH2, CHFCH2, CF2CH2, R1 es un oxígeno que contiene un radical cíclico, seleccionado de C3-C6-cicloalquilo, el cual contiene uno o dos átomos de oxígeno el cual lleva radicales seleccionados del grupo que consiste en OH, C1-02 alcoxi, C1- C
