Abstract "Heterocyclic Carboxamides Useful as Type 10a Phosphodiesterase Inhibitors" The present invention relates to compounds which are type 10a phosphodiesterase inhibitors and their use in the manufacture of a medicament and which are therefore suitable for the treatment or control of Medical disorders selected from neurological disorders and psychiatric disorders, to improve the symptoms associated with such disorders and to reduce the risk of such disorders. . where x1 is ch or n, x2 is c-r5 or n, y is o or s, r1 is inter alia c2-c8-alkyl, c2-c8-alkenyl, c1-c4-fluoroalkyl, c3-c8-cycloalkyl, C5 -C8 cycloalkyl carrying a fused benzene ring, or a z1-ar1 moiety； R 2 is a 5- or 6-membered phenyl or hetaryl radical of formula cr21r22r23 having 1, 2 or 3 heteroatoms as ring members which are selected from o, sen, wherein phenyl and monocyclic hetaryl are unsubstituted. or they may carry 1, 2 or 3 identical or different substituents ra, r 3 is inter alia hydrogen, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 1 -C 4 fluoroalkyl, C 3 -C 8 cycloalkyl, etc., or R 2 and R 3 together with the nitrogen atom to which they are attached form an optionally substituted saturated 5- to 7-membered heterocyclic ring which, in addition to the nitrogen atom, may have 1 or 2 additional heteroatoms or groups containing heteroatoms selected from the group of o, n, s, so and so2； R4 is inter alia C1-C4-alkyl, C1-C4-fluoroalkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C4-alkyl or Z4-Ar4； R5 is inter alia hydrogen, halogen, C1-C4-alkyl, C1-C4-fluoroalkyl, C1-C4-alkoxy, C1-C4-fluoro-alkoxy, -z5-ar5, -o-z5-ar5, etc .； wherein z1 to z5, ar1 to ar5, ra, r21, r22 and r23 are as defined in the claims.resumo “carboxamidas heterocíclicas úteis como inibidores de fosfodiesterase tipo 10ª” a presente invenção refere-se a compostos que são inibidores da fosfodiesterase tipo 10a e a seu uso para a fabricação de um medicamento e que, portanto, são adequados para o tratamento ou controle de distúrbios médicos selec
