您的位置: 首页 > 农业专利 > 详情页

Acilaminocicloalquilo compounds suitable for treating Disorders that respond to Modulation of the Dopamine D3 receptor
专利权人:
ABBVIE INC.;ABBVIE DEUTSCHLAND GMBH & CO. KG
发明人:
DRESCHER, KARLA,DINGES, JÜRGEN,HAUPT,ANDREAS,UNGER, LILIANE,WICKE, KARSTEN,WATERSCHOOT VAN,ANA RELO
申请号:
UY35420
公开号:
UY35420A
申请日:
2014.03.13
申请国别(地区):
UY
年份:
2014
代理人:
摘要:
1. The new formula I hydrazine compounds and their salts and positive oxides described in this specification have valuable therapeutic properties, are particularly suitable for the treatment of Qu diseases, and conform to the modulation of dopamine receptor D3. In formula I, the meaning of variable is as follows: m is 1 or 2, n is 1 or 2, a is selected from CH2, CH2CH2, chfch2 and cf2ch2 groups, R1 is an oxygen-containing cyclic radical substance, such as c3-c6cyclododecane, One or two oxygen-containing radicals were selected from the group of Oh, c1-c2-alcoxi and c1-c2-alcoxi,and a carbonyl oxygen, R2 is selected from the group consisting of hydrogen, OH, and fluorine, R3a is selected from the group consisting of hydrogen and methyl, R3b is selected from the group consisting of hydrogen and methyl, R4 is C4 -C6 branched alkyl or C4-C6 branched fluorinated alkyl, and R5 is inter alia C1-C6 alkyl, C1-C3 fluorinated alkyl, C1-C2-alkoxy-C1-C4-alkyl, C1-C2-alkoxy-C1-C4- fluorinated alkyl, hydroxy-C1-C4-alkyl, hydroxy-C1-C4-fluorinated alkyl, oxethanyl, fluorinated oxetanyl, oxolanyl, fluorinated oxolanyl, C3-C5 cycloalkyl, C3-C5 cycloalkyl fluorinated, etc.Nuevos compuestos de acilaminocicloalquilo de fórmula I que son como se describe en la presente, sus sales y sus N-óxidos, que presentan propiedades terapéuticas valiosas y que resultan particularmente apropiados para tratar aquellas enfermedades qu e responden a la modulación del receptor de dopamina D3. En la fórmula I, las variables tienen los siguientes significados: m es 1 o 2, n es 1 o 2, A se selecciona entre el grupo que consiste en CH2, CH2CH2, CHFCH2 y CF2CH2, R1 es un radical cíclico que contiene oxígeno, por ejemplo C3-C6 cicloalquilo, que tiene uno o dos radicales que contienen oxígeno seleccionados entre el grupo que consiste en OH, C1-C2-alcoxi, C1-C2-alcoxi fluorado, y un oxígeno de carbonilo, R2 se selecciona entre el grupo que consiste en hidrógeno, OH y flúor, R3a se selecciona entre el grupo que co
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充