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SYNTHESIS AND USE OF AMINO LIPIDS
专利权人:
INCELLA GMBH;KARLSRUHER INSTITUT FÜR TECHNOLOGIE
发明人:
Linxian Li,Girish Karadka Shankara,Xing Du,Yihang Wu,Gary Davidson,Pavel Levkin
申请号:
US15324619
公开号:
US20170204076A1
申请日:
2015.07.06
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention provides novel amino lipids and a method for synthesizing these compounds. According to the invention, the amino lipids have a structure of the following formula:wherein Z is hydrogen or —X1R1,R1 and R2 are the same or different and independently C6-C24 alkyl, C6-C24 alkenyl, C6-C24 alkynyl, or C6-C24 acyl,X1 and X2 are the same or different, S, S═O or S(═O)2,Y isor heterocycles of the formulawherein k and l are integers from 0 to 2,R3 and R4 are either the same or different and independently C1-C12 alkyl, C1-C12 alkenyl, or C1-C12 alkynyl, wherein alkyl, alkenyl or alkynyl may be optionally substituted with a C1-C6 hydrocarbyl group, or R3 and R4 optionally join to form, together with the nitrogen atom to which they are bound, an optionally substituted N-heterocyclic ring of 3 to 10 atoms comprising 1 to 7 nitrogen atoms, or R3 and R4 are the same or different alkyl amines;R5 and R6 are absent or are hydrogen or C1-C12 alkyl,R7 is hydrogen or C1-C12 alkyl,m is an integer from 1 to 12, n is an integer from 1 to 12, and p is an integer from 1 to 3, wherein Y═N for p=2 or 3.
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