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5-podstawione pochodne kwasu indolo-3-karboksylowego o działaniu przeciwwirusowym, sposób ich wytwarzania i zastosowanie
专利权人:
Research and development company Medbiopharm Ltd.
发明人:
VERKHOVSKY, JURY GRIGORIEVICH,TSYSHKOVA, NINA GAVRILOVNA,ROZIEV, RAKHIMDZHAN AKHMETDZHANOVICH,TSYB, ANATOLIY FEDOROVICH,GONCHAROVA, ANNA YAKOVLEVNA,TROFIMOV, FEDOR ALEXANDROVICH
申请号:
PL08845963
公开号:
PL2213660T3
申请日:
2008.10.01
申请国别(地区):
PL
年份:
2013
代理人:
摘要:
5-SUBSTITUTED INDOL-3-CARBOXYLIC ACID DERIVATIVES EXHIBITING ANTIVIRAL ACTIVITY, A METHOD FOR THE PRODUCTION AND USE THEREOF The invention relates to novel antiviral compounds of general formula (I), where B is -N(R) 2 or -O-(CH 2 )nN(R) 2 groups, in which n is a whole number selected from 0, 1, 2, 3 and 4, each R is independently selected from C 1-4 alkyl and can be identical or different, or both groups R together with a nitrogen atom, to which they are bonded, form a 5-6-membered heterocyclic ring containing 1-2 heteroatoms selected from nitrogen, oxygen and sulphur, such as pyrrolidine, piperidine, piperazine, morpholine or thyomorpholine, at which each of above-mentioned heterocyclic rings can be substituted by C 1-4 alkyl, phenyl, benzyl, phenetyl, carbonylamino, -COOC 1-4 alkyl group or -COOC 1-4 alkyl group and phenyl, which also can be substituted and have substituents selected from halogen, C 1-4 alkyl, C 1-4 alkoxy, and alkyl in said groups can be linear or branched; R 1 is C 1-4 alkyl, phenyl optionally substituted by C 1-4 alkyl or C 1-4 alkoxy, halogen atoms, naphthyl; R 2 is C 1-4 alkyl, -S-phenyl, -S-benzyl, -O-phenyl, O-benzyl, wherein in each of the above-mentioned groups the phenyl ring is optionally substituted by C 1-4 alkyl, C 1-4 alkoxy, halogen atoms, or R 2 is an -NR 3 R 4 group, in which R 3 and R 4 , each is independently selected from C 1-4 alkyl and can be identical or different, or both R 3 and R 4 groups together with a nitrogen atom, to which they are bonded, form a 5-6-membered nitrogen-containing heterocyclic ring having the above mentioned meaning for the N(R) 2 group; X is hydrogen or a halogen atom selected from Br, Cl, I and pharmaceutically acceptable salts thereof. The invention also relates to intermediate products of the general formula (II) and a method for obtainment of the compounds.
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