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Heterobicyclo-substituted [1,2,4]triazolo[1,5-C]quinazolin-5-amine compounds with A2A antagonist properties
专利权人:
Merck Sharp & Dohme Corp.
发明人:
Amjad Ali,Michael Man-Chu Lo,Yeon-Hee Lim
申请号:
US14655648
公开号:
US09708347B2
申请日:
2013.12.20
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Disclosed are compounds of Formula G1 (structurally represented): where “RG3” “Rd1” to “Rd4”, “n”, “m”, “p”, “W”, “X”, “Y”, and “Z” are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.
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