Present application discloses formula G1 compounds, wherein " RG3 ", " Rd1 "-Rd4 ", " n ", " m ", " p ", " W ", " X ", " Y " and " Z " as defined in this application, the compound is the antagonist of A2A receptor. The application further discloses antagonist purposes in the potential treatment or prevention of the nervous disorders and disease that are wherein related to A2A receptor of the herein described compound as A2a receptor. The application further discloses the purposes of the pharmaceutical composition comprising these compounds He these pharmaceutical compositions.本申請披露了式G1化合物，其中“RG3”、“Rd1”-Rd4”、“n”、“m”、“p”、“W”、“X”、“Y”和“Z”如本申請所定義，所述化合物為A2A受體的拮抗劑。本申請還披露了本申請所述化合物作為A2a受體的拮抗劑在其中涉及A2A受體的神經病症和疾病的潛在治療或預防中的用途。本申請還披露了包含這些化合物的藥物組合物和這些藥物組合物的用途。
