The present invention is directed to pyrrolidin-3-yl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimers disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.Linvention concerne des composés de dérivés pyrrolidin-3-yle qui sont des inhibiteurs de lenzyme bêta-secrétase et qui sont utiles dans le traitement de maladies, telles que la maladie dAlzheimer, dans lesquelles cette dernière est impliquée. Linvention porte également sur des compositions pharmaceutiques comprenant ces composés, sur lutilisation de ces composés et compositions dans le traitement des maladies dans lesquelles la bêta-secrétase est impliquée.
