The present invention is directed to 2,3,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimers disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.La présente invention concerne des dérivés pyridyle 2,3,4,6-substitués qui sont des inhibiteurs de lenzyme bêta-secrétase et qui sont utiles dans le traitement de maladies dans lesquelles lenzyme bêta-secrétase est impliquée, telles que la maladie dAlzheimer. Linvention concerne également des compositions pharmaceutiques comprenant ces composés ainsi que lutilisation de ces composés et de ces compositions dans le traitement de maladies dans lesquelles lenzyme bêta-secrétase est impliquée.
