MESSINGER, JOSEF,THOLE, HEINRICH-HUBERT,HUSEN, BETTINA,KOSKIMIES, PASI,KALLIO, LILA,WESKE, MICHAEL
申请号：
CA2609726
公开号：
CA2609726C
申请日:
2006.05.24
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17.beta.-hydroxysteroid dehydrogenase type I (17.beta.-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17.beta.-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17.beta.-estradiol concentration.
