Josef Messinger,Heinrich-Hubert Thole,Bettina Husen,Michael Weske,Pasi Koskimies,Lila Pirkkala
申请号：
US12892351
公开号：
US08435973B2
申请日:
2010.09.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Substituted steroid compounds which represent selective inhibitors of 17β-hydroxysteroid dehydrogenase type I (17β-HSD1) and, in addition, which may represent inhibitors of the steroid sulfatase, salts thereof, pharmaceutical preparations containing these compounds, and a process for the preparation of these compounds. Also disclosed is a therapeutic method of using such substituted steroid compounds, particularly in the treatment, inhibition, prophylaxis or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17β-hydroxysteroid dehydrogenase type I and/or steroid sulfatase enzymes and/or requiring lowering of the endogenous 17β-estradiol concentration.
