Gunnar J. Hanson,Alexander Charles Rudolph,Bao Zhong Cai,Ming Zhou,Dwight D. Weller
申请号:
US16225909
公开号:
US20190218551A1
申请日:
2018.12.19
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′; and/or 5′;-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.