GRIFFITH, DAVID ANDREW,DOW, ROBERT LEE,SOUTHERS, JR., JAMES ALFRED,EDMONDS, DAVID JAMES
申请号：
PE0023872013
公开号：
PE11872014A1
申请日:
2012.04.09
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to a compound of formula (i), where G Is A (ii) r1 is alkyl, cycloalkyl (C1 - C6) (C3 - C7) R2 is indolilo, indazolilo, pirrolopiridinilo, among others, R3 is Hydrogen or alkyl (C1 - C3).Preferred compounds are 6 - [(1 - 7 1,4,6,7 isopropyl - - oxo - tetrahydro - 1 - H - piperidin indazol spiro [5.4] - 1 - yl) carbonyl] - 1H indole - 3 - carboxamide 5 - [(1 - 7 1,4,6,7 isopropyl - - oxo - tetrahydro - 1 - H - - indazol spiro [5.4] piperidin - 1 - yl) carbonyl] - 1H - indazol - 3 - carboxamide, among others.It also relates to a Pharmaceutical composition that is useful in the treatment of diseases, Disorders or Disorders Modulated by the inhibition of an enzyme acetyl CoA carboxylase in an animal.REFERIDO A UN COMPUESTO DE LA FORMULA (I), DONDE: G ES (II) R1 ES UN ALQUILO (C1-C6), CICLOALQUILO (C3-C7) R2 ES INDOLILO, INDAZOLILO, PIRROLOPIRIDINILO, ENTRE OTROS, R3 ES HIDROGENO O ALQUILO (C1-C3). SON COMPUESTOS PREFERIDOS 6-[(1-ISOPROPIL-7-OXO-1,4,6,7-TETRAHIDRO-1H-ESPIRO[INDAZOL-5,4PIPERIDIN]-1-IL)CARBONIL]-1H-INDOL-3-CARBOXAMIDA 5-[(1-ISOPROPIL-7-OXO-1,4,6,7-TETRAHIDRO-1H-ESPIRO[INDAZOL-5,4-PIPERIDIN]-1-IL)CARBONIL]-1H-INDAZOL-3-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES, AFECCIONES O TRASTORNOS MODULADOS POR LA INHIBICION DE UNA ENZIMA ACETIL-COA CARBOXILASA EN UN ANIMAL.
