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Composés aromatiques d'arylsulfonylmethyl ou arylsulfonamide pour la traitement des maladies concernent la modulation des réceptors de dopamin D3
专利权人:
Abbott GmbH & Co. KG
发明人:
申请号:
EP12150319.7
公开号:
EP2439203A1
申请日:
2005.10.14
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The present invention relates to aromatic compounds of the formula Iwherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical Ra and wherein Ar may also carry 1 or 2 radicals Rb;X is N or CH;Y is O, S, -CH=N-, -CH=CH- or -N=CH-;A is CH2, O or S;E is CR6R7 or NR3;R1 is C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-cycloalkylmethyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-cycloalkylmethyl, fluorinated C3-C4-alkenyl, formyl or C1-C3-alkylcarbonyl;R1a is H, C2-C4-alkyl, C3-C4-cycloalkyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4-cycloalkyl, or R1a and R2 together are (CH2)n with n being 2 or 3, or R1a and R2a together are (CH2)n with n being 2 or 3;R2 and R2a are independently of each other H, CH3, CH2F, CHF2 or CF3;R3 is H or C1-C4-alkyl;R6, R7 independently of each other are selected from H, C1-C2-alkyl and fluorinated C1-C2-alkyl;and the physiologically tolerated acid addition salts thereof.The invention also relates to the use of a compound of the formula I or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.
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