Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
드레셔 카를라,하웁트 안드레아스,운거 릴리아네,터너 신 씨,브라예 빌프리트,그란델 롤란트,앙리 크리스토프
申请号：
KR1020077010954
公开号：
KR1013255190000B1
申请日:
2005.10.14
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
The present invention relates to aromatic compounds of the formula I wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical R a and wherein Ar may also carry 1 or 2 radicals R b ； X is N or CH； Y is O, S, -CH=N-, -CH=CH- or -N=CH-； A is CH 2 , O or S； E is CR 6 R 7 or NR 3 ； R 1 is C 1 -C 4 -alkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -cycloalkylmethyl, C 3 -C 4 -alkenyl, fluorinated C 1 -C 4 -alkyl, fluorinated C 3 -C 4 -cycloalkyl, fluorinated C 3 -C 4 -cycloalkylmethyl, fluorinated C 3 -C 4 -alkenyl, formyl or C 1 -C 3 -alkylcarbonyl； R 1a is H, C 2 -C 4 -alkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -alkenyl, fluorinated C 1 -C 4 -alkyl, fluorinated C 3 -C 4 -cycloalkyl, or R 1a and R 2 together are (CH 2 ) n with n being 2 or 3, or R 1a and R 2a together are (CH 2 ) n with n being 2 or 3； R 2 and R 2a are independently of each other H, CH 3 , CH 2 F, CHF 2 or CF 3 ； R 3 is H or C 1 -C 4 -alkyl； R 6 , R 7 independently of each other are selected from H, C 1 -C 2 -alkyl and fluorinated C 1 -C 2 -alkyl； and the physiologically tolerated acid addition salts thereof. The invention also relates to the use of a compound of the formula I or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.본 발명은 화학식 I의 방향족 화합물 및 생리학적으로 허용되는 이의 산 부가 염에 관한 것이다.화학식 I상기 화학식 I에서,Ar은 페닐 또는 방향족 5-원 또는 6-원의 C-결합된 헤테로방향족 라디칼이고, 여기서, Ar은 1개의 라디칼 Ra을 포함할 수 있고, Ar은 또한 1개 또는 2개의 라디칼 Rb를 포함할 수 있고；X는 N 또는 CH이고；Y는 O, S, -CH=N-, -CH=CH- 또는 -N=CH-이고；A는 CH2, O 또는 S이고；E는 CR6R7 또는 NR3이고；R1은 C1-C4-알킬, C3-C4-사이클로알킬, C3-C4-사이클로알킬메틸, C3-C4-알케닐, 플루오르화된 C1-C4-알킬, 플루오르화된 C3-C4-사이클로알킬, 플루오르화된 C3-C4-사이클로알킬메틸, 플루오르화된 C3-C4-알케닐, 포밀 또는 C1-C3-알킬카보닐이고；R1a는 H, C2-C4-알킬, C3-C4-사이클로알킬, C3-C4-알케닐, 플루오르화된 C1-C4-알킬, 플루오르화된 C3-C4-사이클로알킬이거나, R1a 및 R2는 함께 (CH2)n이거나(여기서, n은 2 또는 3이다), R1a 및 R2a는 함께 (CH2)n이고(여기서
