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4- [Cycloalkyloxy (hetero) arylamino] -thieno [2,3-d] pyrimidines having Mnk1 / Mnk2 inhibitory activity for pharmaceutical compositions
专利权人:
EVOTEC INTERNATIONAL GMBH
发明人:
LEHMANN-LINTZ, THORSTEN,HECKEL, ARMIN,KLEY, JOERG,LANGKOPF, ELKE,REDEMANN, NORBERT,SAUER, ACHIM,THOMAS, LEO,WIEDENMAYER, DIETER,AUSTEN, MATTHIAS,DANILEWICZ, JOHN,SCHNEIDER, MARTIN,SCHREITER, KAY,BLACK
申请号:
ES11707386
公开号:
ES2547905T3
申请日:
2011.02.25
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound of general formula ** Formula ** in which X is CH or N, R1 is a hydrogen or halogen atom, R2 is a cyclopentyl substituted with one or two hydroxy or methoxy groups or with an amino, methylcarbonylamino, Nmethyl group - N-methylcarbonylamino or in which two adjacent carbon atoms are linked together through a group -O-CH2-O- or -OC (CH3) 2-O-, or a cyclohexyl substituted with one or two atoms of fluorine or one or two hydroxy or methoxy groups or an oxo, C1-3-alkoxycarbonyl, morpholino, (methylpiperidinyl) amino or an amino group, in which the amino group hydrogen atoms may be optionally independently substituted with a group methyl, methylcarbonyl, 2-methoxyethyl or methylsulfonyl, or in which two adjacent carbon atoms are linked together through a group -OC (CH3) 2-O- or in which two hydrogen atoms attached to the same atom of carbon are replaced by a group -O- (CH2) 2-O-, R3 a C1-2 alkyl group and R4 is an amino carbonyl or an N- (C1-3 alkyl) -aminocarbonyl group, wherein the methyl moiety of the above-mentioned N- (methyl) aminocarbonyl group may be optionally substituted with a piperidinyl, N-methylpiperidinyl or morpholinyl group, each attached to through a carbon atom and in which ethyl or propyl moiety, respectively, of the above-mentioned N- (C2-3 alkyl) aminocarbonyl group may be optionally substituted terminally with a hydroxy, methoxy, amino, N-methylamino, N group, N-dimethylamino, morpholino, imidazolyl, 4-methylpiperazinyl, 1-methylpyrrolidinyl, piperidinyl, pyrrolidinyl or 4-hydroxypiperidine, in which any hydrogen atom in an alkyl or alkoxy group can be replaced by a fluorine atom or a salt thereof .Un compuesto de fórmula general**Fórmula** en la que X es CH o N, R1 es un átomo de hidrógeno o halógeno, R2 es un ciclopentilo sustituido con uno o dos grupos hidroxi o metoxi o con un grupo amino, metilcarbonilamino, Nmetil- N-metilcarbonilamino o en el que dos átomos de carbono adyacentes están unidos entre sí a través de un grupo -O-CH2-O- o
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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