BACTERIAL GHOST (BG) PRODUCTION PROCESS USING BETAPROPIOLACTONE (BLP) FOR FINAL INACTIVATION

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专利权人:

WERNER LUBITZ

发明人:

LUBITZ, WERNER

申请号：

NZ58666909

公开号：

NZ586669A

申请日:

2009.01.16

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

A method of producing a bacterial ghost preparation using betapropiolactone to inactivate the bacteria. The method can be performed with 0.01-1% (v/v) betapropiolactone at 26-50 degrees Celsius and the bacteria are inactivated for 10-60 min. The bacterial ghosts can be obtained by expressing the lytic protein encoded by the bacteriophage phiX174 gene E. The bacterial ghosts can be used in human or veterinary medicine for vaccination or as an adjuvant.

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