KATIBAH, George Edwin,KANNE, David,SUNG, Leonard,GAUTHIER, Kelsey,GLICKMAN, Laura Hix,LEONG, Justin,MCWHIRTER, Sarah, M.,DUBENSKY, Jr., Thomas, W.
申请号：
PH12017501506
公开号：
PH12017501506A1
申请日:
2017.08.18
申请国别(地区):
PH
年份:
2018
代理人:
摘要：
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes), In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinuclotides present in the composition are 2'-fluoro substituted, bis-3',5'CDNs, and most preferably one or more 2',2"-diF-Rp,Rp, bis-3',5'CDNs.
