CARUSO, MICHELE,BERIA, ITALO,BRASCA, MARIA GABRIELLA,FERGUSON, RON,POSTERI, HELENA,VALSASINA, BARBARA
申请号：
ES07857726
公开号：
ES2527696T3
申请日:
2007.12.17
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of the formula (I): ** Formula ** wherein R1 is an ortho substituted arylamino of the formula: ** Formula ** where R'4 and R "4 are independently selected from a group consisting of halogen, nitro, cyano, C1-C6 alkyl, polyfluorinated alkyl, polyfluorinated alkoxy, alkenyl, alkynyl, hydroxyalkyl, aryl, arylalkyl, heterocyclyl, C3-C6 cycloalkyl, hydroxy, alkoxy, aryloxy, heterocyclyloxy, methylenecarbonyloxy, aryloxycarbonyloxy, aryloxycarbonyloxy, aryloxycarbonyloxy, aryloxycarbonyloxy, aryloxycarbonyloxy, arylcarbonyloxy, aryl , alquilidenoaminoxi, carboxy, alkoxycarbonyl, aryloxycarbonyl, cycloalkyloxycarbonyl, heterocyclyloxycarbonyl, amino, ureido, alkylamino, dialkylamino, arylamino, diarylamino, heterocyclylamino, formylamino, alkylcarbonylamino, arylcarbonylamino, heterocyclylcarbonylamino, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, arylaminocarbonyl, heterocyclylaminocarbonyl, alkoxycarbonylamino, hydroxyaminocarbonyl, alkoxyimino , alkylsulfonylamino, arylsulfonylami no, heterocyclylsulfonylamino, formyl, alkylcarbonyl, arylcarbonyl, cycloalkylcarbonyl, heterocyclylcarbonyl, alkylsulfonyl, arylsulfonyl, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, heterocyclylaminosulfonyl, arphthio, alkylthio, alkylthio； R2 is hydrogen or an optionally substituted group selected from C1-C6 linear or branched alkyl, C2-C6 linear or branched alkenyl, C2-C6 linear or branched alkynyl, C3-C6 cycloalkyl and heterocyclyl； R3 is CO-OR 'or CO-NR'R ", wherein R' and R" are each independently hydrogen or an optionally substituted group of linear or branched C1-C6 alkyl, C3-C6 cycloalkyl, and heterocyclyl or R 'and R "taken together with the hydrogen atom to which they are attached, can form a heterocyclyl group that optionally contains an additional heteroatom selected from N, O or S； and isomers, tautomers, hydrates, solvates, N-oxides and pharmaceutically acceptable salts thereof.Un compuesto de la fórmula (I):**Fórmula** en d
