JOTHAM WADSWORTH COE,CHRISTOPH MARTIN DEHNHARDT,PETER JONES,YOGESH ANIL SABNIS,JOSEPH WALTER STROHBACH,FLORIAN MICHEL WAKENHUT,GAVIN ALISTAIR WHITLOCK
申请号：
NI201600170
公开号：
NI201600170A
申请日:
2016.11.11
申请国别(地区):
NI
年份:
2017
代理人:
摘要：
1. Compounds with structure: (I)Or a pharmaceutically acceptable salt or a pharmaceutically acceptable solution in which a and a 'are independent C or N and may not or may not be substituted by C1-C6 halogen or hydrocarbon in C； R and R0 are independently selected, Including h, C1-C6, hydroxi (C1-C6, C1-C6, C1-C6, C1-C6, C1-C6, C1-C6, C1-C6, C1-C6, C1-C6, C1-C6, C1-C6, C1-C6, C1-C6, C1Phenyl (C1-C6) and - (CH2) N-W, where W is heterocycle of cycloquilo c3-c8, phenyl, naphthalene, 5 or 6 members or containing 1-3 n, s and / or - so2-r atoms,-NHSO2-R-NR "so2-r" and "Sir"R" and "R" are independent C1-C6 or c3-c8 plasma tar；In this case, each asphalt, cyclopropyl, isocyclic, phenyl, northwest non-n-propyl or isopropyl oil may not or may be replaced by phenyl, isopropyl oil, etc；O r and R 0 and the N atoms they connect form a single or double ring heterocyclic ring, which may not be or may be replaced by (a) halogen, hydroxyl, heteromorphic, C1-C6 tar, alcoxi C1-C6, etc., or (b) N-W, where W is cyclo-c3-c8, phenyl, etc；R1 is h, halogen or cyanogen； R2 and R2 'are independent h, C1-C6 tar, cyanogen, Alcoy C1-C6, C1-C6 tar or cyclo-c3-c8, wherein tar, alcoxi or cycloquilo can be replaced by one or more fluorine atoms； X is a bond, - Co,-Well-SO2…-Sonh-o-（ch2）m-；R3 is h, C 1-c4 tar, phenyl, northwest non-n-propene, 5-6 N atoms or non periodic atoms containing 1-3 N atoms, 1 5 member or non periodic atoms, etc., or (c) 2 O or S atoms and 0-2 N atoms； in these substances, each phenyl, northwest non-n-propene, heteromorphic or non periodic can be replaced by asphalt, 1 substitute -Y-r4 and / or 1-4 substitutes, selected from R5 respectively, but when x is - co-o-so2,R3 is not h, it is a link, - (CH2) m-u-o -；R4 is (a) h, C1-C6, c3-c8, halo, oxo, or6, nr7r8, sr6, so9, so2r9, cor6, OCR6, cour6, nr6cor6, conr7r8, etc；(b) Phenyl or nafilo, replaced by 1-5 substitutes selected from the tar such as C1-C6, c3-c8, halogen, cyano-or6, nr7r8, etc；O (c) a saturated or partially unsatura
